Atomwise and Atropos Launch Joint Venture to Discover Senescence Modulating Small Molecules for Cancer Patients

A joint venture between Atropos and Atomwise will discover and develop anticancer agents using senescence assay and AI technologies

SAN FRANCISCO & BELMONT, Calif.–(BUSINESS WIRE)–Atomwise Inc., a leader in artificial intelligence (AI) for drug discovery, and Atropos Therapeutics, Inc., a senescence platform discovery company, announced today that they will launch a joint venture company to discover and advance a pipeline of compounds for promising discovery targets for the treatment of cancer.

Cellular senescence is a regulated biological process by which cells stop dividing irreversibly and is a normal part of aging. However, the failure and induction of senescence also have an important role in the development and treatment of cancers, respectively. Compounds that modulate senescence have enormous potential as novel anticancer agents. Atropos and Atomwise will use their platform technologies and complementary capabilities to perform screens to identify and develop novel compounds for undisclosed targets that modulate cellular senescence and evaluate their potential for development as safe and effective drugs for the treatment of cancer.

“We are excited to be embarking on this joint enterprise with Atomwise. We value the innovation that the two respective teams bring and look forward to working together toward new and better therapies for cancer patients,” said Tommy Nguyen, M.D., Ph.D., CEO and Co-Founder of Atropos.

“This partnership with Atropos is an opportunity to ultimately provide patients with a fundamentally different class of drugs,” said Abraham Heifets, Ph.D., CEO and Co-Founder of Atomwise. “We are excited to apply our technology to targets that are considered to be intractable and advance the discovery and development of drugs that modulate cellular senescence to treat cancer.”

Under the terms of the agreement, the joint venture company will have access to Atropos’ and Atomwise’s cutting-edge technology and expertise in aging, cancer biology, computational and medicinal chemistry, and artificial intelligence for drug discovery.

About Atropos Therapeutics

Founded in 2018, Atropos is a biotechnology platform company focused on the discovery, development, and commercialization of therapies targeting the formation of senescent cells. The company is leveraging unexploited insights in senescence biology to discover agents and modalities. This disruptive approach to “aging” disorders and cancer, targets that which is common to these diseases, the stress-induced accumulation of the senescent cell in various tissues. For more information, please visit www.AtroposThera.com.

About Atomwise

Atomwise Inc. invented the first deep learning AI technology for structure-based small molecule drug discovery. Created in 2012, today Atomwise performs hundreds of projects per year in partnership with some of the world’s largest pharmaceutical and agrochemical companies, as well as hundreds of universities and hospitals in 19 countries. Atomwise has raised over $50 million from leading venture capital firms to support the development and application of its AI technology. Learn more at www.Atomwise.com or follow @AtomwiseInc.

Contacts

Atropos Therapeutics

Ethan Than

ethan@atroposthera.com

Atomwise

Sara Dunn

SDunn@jpa.com

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